PKRRATING FOR DUMMIES

The interfacial residues are very conserved among eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements show that the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations assistance a model where activating RNA serves for a scaffold to bind numerous PKR monomers, escalating the are

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